Use of Augmentin (Amoxycillin and Clavulanate)

Amoxicillin and clavulanate combination may be taken on a full or empty stomach. Taking amoxicillin and clavulanate combination with food may decrease the chance of diarrhea, nausea, and vomiting.

For patients taking the oral liquid form of amoxicillin and clavulanate combination:

Use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.
Do not use after the expiration date on the label. The medicine may not work properly after that date. If you have any questions about this, check with your pharmacist.
For patients taking the chewable tablet form of amoxicillin and clavulanate combination:

Tablets should be chewed or crushed before they are swallowed.
To help clear up your infection completely, keep taking Augmentin (Amoxycillin and Clavulanate) for the full time of treatment, even if you begin to feel better after a few days.

Augmentin (Amoxycillin and Clavulanate) works best when there is a constant amount in the blood or urine. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times, day and night. For example, if you are to take four doses a day, the doses should be spaced about 6 hours apart. If this interferes with your sleep or other daily activities, or if you need help in planning the best times to take your medicine, check with your health care professional.

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Dose of Augmentin (Amoxycillin and Clavulanate)

The dose of Augmentin (Amoxycillin and Clavulanate) will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Augmentin (Amoxycillin and Clavulanate). If your dose of Augmentin (Amoxycillin and Clavulanate) is different, do not change it unless your doctor tells you to do so.

The number of tablets or teaspoonfuls of suspension that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking Augmentin (Amoxycillin and Clavulanate).

For bacterial infections:

For oral dosage forms (chewable tablets and suspension):

Adults, teenagers, and children weighing more than 40 kilograms (kg) (88 pounds)—250 to 500 milligrams (mg) of amoxicillin, in combination with 125 mg of clavulanate, every eight hours or 500 to 875 mg of amoxicillin, in combination with 125 mg of clavulanate, every twelve hours.

Neonates and infants up to 12 weeks (3 months) of age—Dose is based on body weight and must be determined by your doctor. The usual dose is 15 mg of amoxicillin per kg (6.8 mg per pound) of body weight every twelve hours.

Infants 3 months of age and older and children weighing up to 40 kg (88 pounds)—6.7 to 22.5 mg of amoxicillin per kg (3 to 10.2 mg per pound) of body weight, in combination with 1.7 to 3.2 mg of clavulanate per kg (0.8 to 1.5 mg per pound) of body weight, every eight or twelve hours.

For oral dosage form (tablets):

Adults, teenagers, and children weighing more than 40 kg (88 pounds)—250 to 500 mg of amoxicillin, in combination with 125 mg of clavulanate, every eight hours or 500 to 875 mg of amoxicillin, in combination with 125 mg of clavulanate, every twelve hours.
Infants and children weighing up to 40 kg (88 pounds)—The amoxicillin and clavulanate combination tablets are too strong for children weighing less than 40 kg (88 pounds). The chewable tablets or oral suspension are used in these children.

Missed Dose of Augmentin (Amoxycillin and Clavulanate)

If you miss a dose of Augmentin (Amoxycillin and Clavulanate) , apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

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Storage of Augmentin (Amoxycillin and Clavulanate)

Keep Augmentin (Amoxycillin and Clavulanate) out of the reach of children.
Store Augmentin (Amoxycillin and Clavulanate) away from heat and direct light.
Do not store Augmentin (Amoxycillin and Clavulanate) in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause Augmentin (Amoxycillin and Clavulanate) to break down.
Do not keep outdated Augmentin (Amoxycillin and Clavulanate) or Augmentin (Amoxycillin and Clavulanate) no longer needed.
Be sure that any discarded medicine is out of the reach of children. Keep out of the reach of children.

Precautions While Using Augmentin (Amoxycillin and Clavulanate)

If your symptoms do not improve within a few days, or if they become worse, check with your doctor.

Augmentin (Amoxycillin and Clavulanate) may cause diarrhea in some patients.

Check with your doctor if severe diarrhea occurs . Severe diarrhea may be a sign of a serious side effect. Do not take any diarrhea medicine. Diarrhea medicines may make your diarrhea worse or make it last longer.

For mild diarrhea, diarrhea medicine containing kaolin or attapulgite (e.g., Kaopectate tablets, Diasorb) may be taken. However, other kinds of diarrhea medicine should not be taken. They may make your diarrhea worse or make it last longer.

If you have any questions about this or if mild diarrhea continues or gets worse, check with your health care professional.

For patients with diabetes:

Augmentin (Amoxycillin and Clavulanate) may cause false test results with some urine sugar tests. Check with your doctor before changing your diet or the dosage of your diabetes medicine.

Before you have any medical tests, tell the doctor in charge that you are taking Augmentin (Amoxycillin and Clavulanate). The results of some tests may be affected by Augmentin (Amoxycillin and Clavulanate).

Side Effects of Augmentin (Amoxycillin and Clavulanate)

Along with its needed effects, Augmentin (Amoxycillin and Clavulanate) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Stop taking Augmentin (Amoxycillin and Clavulanate) and get emergency help immediately if any of the following side effects occur:

Less common
Cough; fast or irregular breathing; fever; joint pain; lightheadedness or fainting (sudden); pain, redness, or swelling at site of injection; puffiness or swelling around the face; red, irritated eyes ; shortness of breath; skin rash, hives, itching; sore mouth or tongue; unusual tiredness or weakness; vaginal itching and discharge; white patches in mouth and/or on tongue

In addition to the side effects mentioned above, check with your doctor immediately if any of the following side effects occur:

Rare
Abdominal or stomach cramps and pain (severe); blistering, peeling, or loosening of skin and mucous membranes; chest pain; cloudy urine; convulsions (seizures); diarrhea (watery and severe), which may also be bloody; general feeling of illness or discomfort; nausea or vomiting; redness, soreness, or swelling of tongue; red skin lesions, often with a purple center; sore throat; swelling of face, fingers, lower legs, or feet; trouble in urinating; unusual bleeding or bruising; weight gain; yellow eyes or skin

Some of the above side effects (severe abdominal or stomach cramps and pain, and watery and severe diarrhea, which may also be bloody) may also occur up to several weeks after you stop taking any of these medicines.

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:

More common
Diarrhea (mild); gas; headache; stomach pain; swelling of abdomen

Less common or rare
Chills; nosebleed; long-lasting muscle relaxation (with piperacillin and tazobactam combination) ; unusual tiredness or weakness

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

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